Revealed: ALL of the side effects

Novo has no intention of developing a miraculous medication for weight loss. The Danish company has spent decades developing a medication that helps people with type 2 diabetes control their insulin levels.

Liraglutide, marketed under the names Victoza (authorized in 2010 for diabetes) and Saxenda (approved in 2014 for weight loss), was their first successful product.

The long-acting GLP-1 counterpart semaglutide was then created. They altered the molecule's structure to make it adhere to blood proteins and withstand degradation by adding a fatty acid chain. The outcome? A medication that is administered once a week rather than every day.

Early in the 2010s, semaglutide began clinical studies, and the first significant study findings were released in 2016. These soon exposed a potent adverse effect: patients were reporting previously unheard-of weight reduction and significantly reduced appetites.

The race to reframe semaglutide as a slimming agent had already started when the Danish pharmaceutical behemoth realized what it had.

Novo changed course and started a significant clinical trial especially for obesity, this time utilizing a little greater dose of semaglutide, because the weight loss effects were so noticeable. In 2021, the New England Journal of Medicine (NEJM) published historic findings that garnered international attention.

​The patients dropped an average of 15% of their body weight, or the first 6 pounds, which was a result of stomach shrinkage surgery. In contrast, people who received a placebo and followed the identical 500-calorie diet and exercise regimen only lost 2.6 kg (6 lbs). Experts disregarded side effects including nausea and diarrhea as "predictable" and not severe enough to cause concern.

Semaglutide was authorized later that year under the new Wegovy brand. In the battle against obesity, Novo celebrated it as the start of "a new era."

Date of Release for the Air Jordan 1 Self Expression
​
On August 9, 2025, the Air Jordan 1 High OG "Self Expression" will go on sale at a few Jordan Brand locations, online, and on Nike.com. The sneakers will cost $140 for grade school sizes and $180 for men's sizes.

In addition to honoring Jordan Brand's heritage, this special edition encourages fans to show off their personality. Prepare to pick up your pair and begin personalizing!

​This is the first up-close look at the Air Jordan 1 "Self Expression." The all-black upper of this sneaker conceals a distinctive twist underneath. Over time, the black paint fades, exposing a vibrant, unique design underneath. Every pair will have a unique appearance.

It's not Wall Street power brokers or Silicon Valley tech giants. According to a recent survey, the highest cocaine use in the country is seen among residents of cities in the Rocky Mountain and Southwest regions of the United States.

According to the American Addiction Centers, Phoenix, Arizona, has the highest rate of cocaine use in the nation, with almost 23% of its adult population having used the drug at least once.

With almost 22.5 percent of respondents reporting having used the drug at some point, Mesa, Arizona, came in second. Additionally, both cities were among the top 10 cities in terms of the proportion of residents who had smoked marijuana.

With the exception of Phoenix, all of the cities on the list have populations under 632,000, although all reported cocaine consumption rates above 21%.

Cocaine has a strong potential for abuse but also has medical uses because it is classified as a Schedule Two drug by the Drug Enforcement Administration, which also places it in the same category as morphine and amphetamines, including those used to treat ADHD.

The 1980s saw a spike in cocaine use, particularly among the upper-middle class and wealthy, and a peak in illicit manufacturing and trafficking during that time.

Due to the explosive growth of opioids in the illegal drug market and the decline in the price of coca in Colombia, usage fell in the early 2010s. However, public health professionals have cautioned that the stimulant is making a huge resurgence.

​The following cities had the highest rates of cocaine use: Mesa, Omaha, Nebraska (22.2 percent), Oklahoma City, Oklahoma (22%), and Las Vegas, Nevada (21.9 percent).

The cities with the highest percentage of people who have taken cocaine are Tulsa, Oklahoma; Wichita, Kansas; Colorado Springs, Colorado; Tucson, Arizona; and Fresno, California.

California , Arizona, Nevada, Nebraska , Kansas, Colorado and Oklahoma

Apple AirTag Tracking Device, 4-Pack with 1-Year Apple Warranty
​Product Description
Never worry about losing devices and other belongings again with the Apple Air Tag. This sleek tracking disc can be slipped into a wallet or tablet case, or you can use an optional accessory to key it with your keys or attach it to a purse, bag, or backpack. Wherever the Air Tag goes, you can use Apple's Find My app to find it. When it's nearby, use the Find My app to locate it, have your Air Tag play a sound through its built-in speaker, or you can simply say, "Hey Siri, find my key." . Notifications can also be viewed on an Apple Watch, and if you own an iPhone 11 or 12, you can take advantage of Precision Finding. If your item is truly lost, you can even employ the wider Find My network of Apple devices to locate it. This item includes 4 Air Tags that can be used in multiple items or shared with your family.

Precision Finding
If you own an iPhone 11 or iPhone 12, its Ultra Wideband technology will let you take advantage of the Precision Finding feature. Like something out of a sci-fi novel, Precision Finding helps you pinpoint the Air Tag's exact location and assists you in tracking it on your iPhone. You will get a large arrow on your screen that points in the direction of the Air Tag, along with the exact distance it is from you.

Find My Network
If your Air Tag is truly lost and not anywhere near you, don't worry. Through Apple's Find My network of devices, you can track its location. It works by sending out a Bluetooth signal that's picked up by any Find My-equipped device nearby. That means anyone's iPhone, iPad, or Mac can possibly be used to help you find your belongings. If anyone's device detects it, your Air Tag's location is sent to iCloud and you will see it on the map in the Find My app. The entire process is both anonymous and encrypted for you and everyone else's device.

Lost Mode
When you activate Lost Mode to find your Air Tag, you can get notifications with where it was last spotted through the Find My network. It also gives you the ability to allow your contact information to be seen by those that have your Air Tag, even if they are not an Apple customer. Anyone with an NFC-equipped smartphone can tap your Air Tag to see your contact information.

Privacy Features
Keeping your data and items safe is paramount with the Apple Air Tag. When using the Find My network to track down your item, the entire process is done anonymously and all data sent regarding it is encrypted. Also, your location data and Air Tag history are never stored on the Air Tag itself.

Unwanted Tracking
If an Air Tag accidentally or purposely finds its way into your bag or belongings, Apple has a feature to prevent any unwanted tracking of you. Your iPhone will detect any unpaired Air Tag travelling with you and send you an alert. If you continue to travel with it or just can't find it in your stuff, the Air Tag will automatically start playing a sound to help you locate it. If you happen to be travelling with friends and their Air Tags, don't worry, this unwanted tracking feature only activates on Air Tags that have been separated from their owner.

One-Tap Setup
To pair an Air Tag with an iPhone or iPad, simply tap it with your device. During setup, you can rename each Air Tag you own to better track multiple items and devices.

Long & Replaceable Battery
The Apple Air Tag lasts for over a year and its standard battery is user replaceable when needed. When your Air Tag battery is running low, it will send you a notification on your iPhone.

Water & Dust Resistant
With IP67-rated water and dust resistance, the Air Tag can handle rain, splashed, and even being dropped into a puddle.